Synthesis and SAR of Benzimidazole Derivatives Containing Oxycyclic Pyridine as a Gastric H+/K+ -ATPase Inhibitors 


Vol. 22,  No. 11, pp. 1217-1223, Nov.  2001


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  Abstract

A series of benzimidazole derivatives containing oxycyclic pyridine was prepared and evaluated for their gastric H+ /K+ -ATPase inhibitory activity. Several of the synthesized compound exhibited potent antisecretion in pylorus-ligated rats when administered intradoudenally. Their inhibitory activities were equivalent or comparable to omeprazole.

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[IEEE Style]

S. Y. Cho, S. K. Kang, S. S. Kim, H. G. Cheon, J. Choi, E. K. Yum, K. Hwang, "Synthesis and SAR of Benzimidazole Derivatives Containing Oxycyclic Pyridine as a Gastric H+/K+ -ATPase Inhibitors," Bulletin of the Korean Chemical Society, vol. 22, no. 11, pp. 1217-1223, 2001. DOI: .

[ACM Style]

Sung Yun Cho, Seung Kyu Kang, Sung Soo Kim, Hyae Gyeong Cheon, Joong-Kwon Choi, Eul Kgun Yum, and Ki-Jun Hwang. 2001. Synthesis and SAR of Benzimidazole Derivatives Containing Oxycyclic Pyridine as a Gastric H+/K+ -ATPase Inhibitors. Bulletin of the Korean Chemical Society, 22, 11, (2001), 1217-1223. DOI: .

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949