Synthesis and COX Inhibitory Activities of Rutaecarpine Derivatives 


Vol. 26,  No. 12, pp. 1975-0, Dec.  2005
10.5012/bkcs.2005.26.12.1975


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  Abstract

A series of substituted rutaecarpines were prepared by employing Fischer indole synthesis as key step and their inhibitory activities on COX-1 and 2 as well as selectivity on COX-2 were evaluated. The compounds with a methanesulfonyl and a bromo group at C10 showed promising inhibitory activity (I50 = 0.27, 0.35 μM, respectively) with selectivity.

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  Cite this article

[IEEE Style]

E. S. Lee, S. I. Kim, S. H. Lee, T. C. Jeong, T. C. Moon, H. W. Chang, Y. Jahng, "Synthesis and COX Inhibitory Activities of Rutaecarpine Derivatives," Bulletin of the Korean Chemical Society, vol. 26, no. 12, pp. 1975-0, 2005. DOI: 10.5012/bkcs.2005.26.12.1975.

[ACM Style]

Eung Seok Lee, Seung Ill Kim, Seung Hoo Lee, Tae Cheon Jeong, Tae Chul Moon, Hyeun Wook Chang, and Yurngdong Jahng. 2005. Synthesis and COX Inhibitory Activities of Rutaecarpine Derivatives. Bulletin of the Korean Chemical Society, 26, 12, (2005), 1975-0. DOI: 10.5012/bkcs.2005.26.12.1975.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949