Protective Effect of the Coffee Diterpenes Kahweol and Cafestol on tert-Butyl Hydroperoxide-induced Oxidative Hepatotoxicity 


Vol. 27,  No. 9, pp. 1386-1392, Sep.  2006
10.5012/bkcs.2006.27.9.1386


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  Abstract

Kahweol and cafestol significantly reduced t-BHP-induced oxidative injuries in cultured rat hepatocytes, as determined by cell cytotoxicity, intracellular glutathione (GSH) content and lipid peroxidation in a dosedependent manner. In addition, kahweol and cafestol provided good protection from the t-BHP-induced production of intracellular reactive oxygen species and DNA damage. The in vivo study showed that pretreatment with kahweol and cafestol prior to the administration of t-BHP significantly prevented the increase in serum levels of hepatic enzyme markers (alanine aminotransferase and aspartate aminotransferase) and reduced oxidative stress, such as GSH content and lipid peroxidation, in the liver in a dose-dependent manner. The histopathological evaluation of the livers also revealed that kahweol and cafestol reduced the incidence of liver lesions induced by t-BHP. Taken together, these results support the anti-oxidative role of kahweol and cafestol and demonstrate that kahweol and cafestol can protect hepatocytes from oxidative stress.

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  Cite this article

[IEEE Style]

S. Y. Choi, K. J. Lee, H. G. Kim, E. H. Han, Y. C. Chung, N. J. Sung, H. G. Jeong, "Protective Effect of the Coffee Diterpenes Kahweol and Cafestol on tert-Butyl Hydroperoxide-induced Oxidative Hepatotoxicity," Bulletin of the Korean Chemical Society, vol. 27, no. 9, pp. 1386-1392, 2006. DOI: 10.5012/bkcs.2006.27.9.1386.

[ACM Style]

Sun Young Choi, Kyung Jin Lee, Hyung Gyun Kim, Eun Hee Han, Young Chul Chung, Nak Ju Sung, and Hye Gwang Jeong. 2006. Protective Effect of the Coffee Diterpenes Kahweol and Cafestol on tert-Butyl Hydroperoxide-induced Oxidative Hepatotoxicity. Bulletin of the Korean Chemical Society, 27, 9, (2006), 1386-1392. DOI: 10.5012/bkcs.2006.27.9.1386.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949