Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects 


Vol. 28,  No. 6, pp. 970-0, Jun.  2007
10.5012/bkcs.2007.28.6.970


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  Abstract

For the development of novel hepatoprotective agents, C11, C28, C2,3,23 or C2,23,28 functional groups on asiatic acid were modified, and their hepatoprotective effects were evaluated. Most of the prepared compounds displayed potent hepatoprotective activities against CCl4- and galactosamine (GaIN)-induced hepatotoxicity. Especially, compounds 16 and 20 showed the most significant hepatoprotective effects against GaIN-induced hepatotoxicity (54.2% and 46.4% protection at 50 mM, respectively).

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  Cite this article

[IEEE Style]

L. Zhao, H. Park, S. Jew, M. K. Lee, Y. C. Kim, P. Thapa, R. Karki, Y. Jahng, B. Jeong, E. Lee, "Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects," Bulletin of the Korean Chemical Society, vol. 28, no. 6, pp. 970-0, 2007. DOI: 10.5012/bkcs.2007.28.6.970.

[ACM Style]

Long-Xuan Zhao, Hyeung-geun Park, Sang-sup Jew, Mi Kyeong Lee, Young Choong Kim, Pritam Thapa, Radha Karki, Yurngdong Jahng, Byeong-Seon Jeong, and Eung-Seok Lee. 2007. Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects. Bulletin of the Korean Chemical Society, 28, 6, (2007), 970-0. DOI: 10.5012/bkcs.2007.28.6.970.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949