Determination and Temperature Dependence of n-Octanol/Water Partition Coefficients for Seven Sulfonamides from (298.15 to 333.15) K 


Vol. 28,  No. 7, pp. 1183-0, Jul.  2007
10.5012/bkcs.2007.28.7.1183


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  Abstract

A shake-flask method was used to determine the n-octanol/water partition coefficients of sulfamethazine, sulfadimethoxine, sulfamethoxydiazine, sulfamonomethoxine, sulfamethoxazole, sulfaquinoxaline and sulfachloropyrazine from (298.15 to 333.15) K. The results showed that the n-octanol/water partition coefficient of each sulfonamide decreased with the increase of temperature. Based on the fluid phase equilibrium theory, the thermodynamic relationship of n-octanol/water partition coefficient depending on the temperature is proposed, and the changes of enthalpy, entropy, and the Gibbs free energy function for sulfonamides partitioning in n-octanol/ water are determined, respectively. Sulfonamides molecules partitioning in n-octanol/water is mainly an enthalpy driving process, during which the order degrees of system increased. The temperature effect coefficient of n-octanol/water partition coefficient is discussed. The results show that its magnitude is the same as that of values in the literature.

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  Cite this article

[IEEE Style]

Z. Congliang, W. Yan, W. Fuan, "Determination and Temperature Dependence of n-Octanol/Water Partition Coefficients for Seven Sulfonamides from (298.15 to 333.15) K," Bulletin of the Korean Chemical Society, vol. 28, no. 7, pp. 1183-0, 2007. DOI: 10.5012/bkcs.2007.28.7.1183.

[ACM Style]

Zhang Congliang, Wang Yan, and Wang Fuan. 2007. Determination and Temperature Dependence of n-Octanol/Water Partition Coefficients for Seven Sulfonamides from (298.15 to 333.15) K. Bulletin of the Korean Chemical Society, 28, 7, (2007), 1183-0. DOI: 10.5012/bkcs.2007.28.7.1183.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949