Catalytic Enantioselective Fluorination Reactions of α-Cyano Acetates and α-Cyanophosphonates Using Chiral Palladium Complexes 


Vol. 28,  No. 12, pp. 2435-0, Dec.  2007
10.5012/bkcs.2007.28.12.2435


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  Abstract

The catalytic enantioselective electrophilic fluorinations of active methane compounds promoted chiral palladium complexes have been developed. Treatment of α-cyano acetates and α-cyanoalkylphosphonates with N-fluorobenzenesulfonimide as the fluorine source under mild reaction conditions afforded the corresponding α-cyano-α-fluorinated adducts in high yields with excellent enantiomeric excesses (up to 99% ee). These reactions can be conducted in alcoholic solvents without any precaution to exclude water and moisture.

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  Cite this article

[IEEE Style]

S. M. Kim, Y. K. Kang, M. J. Cho, J. Y. Mang, D. Y. Kim, "Catalytic Enantioselective Fluorination Reactions of α-Cyano Acetates and α-Cyanophosphonates Using Chiral Palladium Complexes," Bulletin of the Korean Chemical Society, vol. 28, no. 12, pp. 2435-0, 2007. DOI: 10.5012/bkcs.2007.28.12.2435.

[ACM Style]

Sun Mi Kim, Young Ku Kang, Min Je Cho, Joo Yang Mang, and Dae Young Kim. 2007. Catalytic Enantioselective Fluorination Reactions of α-Cyano Acetates and α-Cyanophosphonates Using Chiral Palladium Complexes. Bulletin of the Korean Chemical Society, 28, 12, (2007), 2435-0. DOI: 10.5012/bkcs.2007.28.12.2435.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949