Synthesis of Methyl-substituted Bicyclic Carbanucleoside Analogs as Potential Antiherpetic Agents 


Vol. 29,  No. 10, pp. 1977-1982, Oct.  2008
10.5012/bkcs.2008.29.10.1977


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  Abstract

Novel bicyclo[3.1.0]hexanyl purine nucleoside analogues were synthesized as potential antiherpetic agents via a bicyclo[3.1.0]hexanol (±)-8, which was prepared using a highly efficient carbenoid cycloaddition reaction. A highly diastereoselective reduction of ketone and a Mitsunobu reaction for the condensation of glycosyl donor (±)-12 with 6-chloropurine were employed.

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  Cite this article

[IEEE Style]

K. R. Kim, A. Y. Park, H. R. Lee, J. A. Kang, W. H. Kim, P. Chun, J. H. Bae, L. S. Jeong, H. R. Moon, "Synthesis of Methyl-substituted Bicyclic Carbanucleoside Analogs as Potential Antiherpetic Agents," Bulletin of the Korean Chemical Society, vol. 29, no. 10, pp. 1977-1982, 2008. DOI: 10.5012/bkcs.2008.29.10.1977.

[ACM Style]

Kyung Ran Kim, Ah Young Park, Hyung Rock Lee, Jin Ah Kang, Won Hee Kim, Pusoon Chun, Jang Ho Bae, Lak Shin Jeong, and Hyung Ryong Moon. 2008. Synthesis of Methyl-substituted Bicyclic Carbanucleoside Analogs as Potential Antiherpetic Agents. Bulletin of the Korean Chemical Society, 29, 10, (2008), 1977-1982. DOI: 10.5012/bkcs.2008.29.10.1977.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949