Design and Synthesis of 5''-Iodoneplanocin A and Its Analogues as Potential S-Adenosylhomocysteine Hydrolase Inhibitor† 


Vol. 29,  No. 12, pp. 2487-2490, Dec.  2008
10.5012/bkcs.2008.29.12.2487


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  Abstract

5''-Iodoneplanocin A (1) and its analogues 2 and 3 were designed and synthesized as potential SAHH inhibitor via iodocyclopentenol 6, which was prepared using a Michael addition-iodination-elimination process. All final compounds did not show antiviral activity, maybe due to a steric hindrance induced by 5''-iodo substituent.

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  Cite this article

[IEEE Style]

A. Y. Park, K. R. Kim, H. R. Lee, J. A. Kang, W. H. Kim, P. Chun, P. Ahmad, L. S. Jeong, H. R. Moon, "Design and Synthesis of 5''-Iodoneplanocin A and Its Analogues as Potential S-Adenosylhomocysteine Hydrolase Inhibitor†," Bulletin of the Korean Chemical Society, vol. 29, no. 12, pp. 2487-2490, 2008. DOI: 10.5012/bkcs.2008.29.12.2487.

[ACM Style]

Ah Young Park, Kyung Ran Kim, Hyung Rock Lee, Jin Ah Kang, Won Hee Kim, Pusoon Chun, Pervez Ahmad, Lak Shin Jeong, and Hyung Ryong Moon. 2008. Design and Synthesis of 5''-Iodoneplanocin A and Its Analogues as Potential S-Adenosylhomocysteine Hydrolase Inhibitor†. Bulletin of the Korean Chemical Society, 29, 12, (2008), 2487-2490. DOI: 10.5012/bkcs.2008.29.12.2487.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949