Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells 


Vol. 31,  No. 4, pp. 929-933, Apr.  2010
10.5012/bkcs.2010.31.4.929


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  Abstract

A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-棺-D-glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the function of osteoblastic MC3T3-E1 cells was examined by determining alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Compound 1 significantly increased the function of osteoblastic MC3T3-E1 cells; 5.0 關M of 1 increased ALP activity, collagen synthesis, and mineralization of MC3T3-E1 cells to 114.7, 119.5, and 108.2% (P < 0.05) of the basal value, respectively. In addition, compounds 2-10 also potently increased the function of osteoblastic MC3T3-E1 cells.

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  Cite this article

[IEEE Style]

Y. Ding, C. Liang, H. T. Nguyen, E. M. Choi, J. A. Kim, Y. H. Kim, "Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells," Bulletin of the Korean Chemical Society, vol. 31, no. 4, pp. 929-933, 2010. DOI: 10.5012/bkcs.2010.31.4.929.

[ACM Style]

Yan Ding, Chun Liang, Huu Tung Nguyen, Eun Mi Choi, Jeong Ah Kim, and Young Ho Kim. 2010. Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells. Bulletin of the Korean Chemical Society, 31, 4, (2010), 929-933. DOI: 10.5012/bkcs.2010.31.4.929.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949