Liquid Crystal-based Imaging of Biomolecular Interactions at Roller Printed Protein Surfaces 


Vol. 31,  No. 5, pp. 1223-1227, May  2010
10.5012/bkcs.2010.31.5.1223


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  Abstract

In this study, the orientational behavior of thermotropic liquid crystals (LC) supported on a film of protein receptors was examined. Avidin was roller printed and covalently immobilized onto the surface of gold using NHS/EDC chemistry. The orientation of nematic 4-cyano-4’-pentylbiphenyl (5CB) was found to be parallel to the plane of the printed avidin surface before incubation with a solution of biotin. However, protein-receptor complexation induced a random orientation of 5CB, where protein-receptor complexes disturbed the nanoscale topography of the printed protein surface. Atomic force microscopy and ellipsometry was used to confirm printing and the specific interaction of proteins. These results demonstrate that the combination of LC and roller printing can be used to detect specific interactions between biomolecules by manipulating the orientational behavior of LC to the printed protein surfaces.

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  Cite this article

[IEEE Style]

M. K. Park and C. H. Jang, "Liquid Crystal-based Imaging of Biomolecular Interactions at Roller Printed Protein Surfaces," Bulletin of the Korean Chemical Society, vol. 31, no. 5, pp. 1223-1227, 2010. DOI: 10.5012/bkcs.2010.31.5.1223.

[ACM Style]

Min Kyung Park and Chang Hyun Jang. 2010. Liquid Crystal-based Imaging of Biomolecular Interactions at Roller Printed Protein Surfaces. Bulletin of the Korean Chemical Society, 31, 5, (2010), 1223-1227. DOI: 10.5012/bkcs.2010.31.5.1223.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949