4-Hydroxy-2’-Nitrodiphenyl Ether Analogues as Novel Tyrosinase Inhibitors 


Vol. 31,  No. 5, pp. 1319-1325, May  2010
10.5012/bkcs.2010.31.5.1319


PDF
  Abstract

Tyrosinase ubiquitously existing from microorganisms to animals and plants is known to be the most critical and rate limiting enzyme during melanin biosynthesis. In order to develop new tyrosinase inhibitor we have synthesized 14 diphenyl ether compounds possessing hydroxyl, bromo, and nitro groups in the structure. Among the compounds prepared, 18 and 19 have shown much stronger inhibition of tyrosinase monophenolase function than arbutin used as a positive control. Both compounds 18 and 19 possess para-hydroxyphenyl moiety in their structure, which might reinforce the importance of p-hydroxyphenyl group in the tyrosinase inhibitory process. In the DPPH radical scavenging activity test, none of the compounds even 18 and 19 showed significant antioxidant activity. The results suggest that elaborate adjustment of diphenyl ether analogues with proper substituents have potential to be developed as new skin whitening agents working on the tyrosinase function.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

K. Sapkota, E. Lee, J. H. Yang, Y. Kwon, J. Choi, Y. Na, "4-Hydroxy-2’-Nitrodiphenyl Ether Analogues as Novel Tyrosinase Inhibitors," Bulletin of the Korean Chemical Society, vol. 31, no. 5, pp. 1319-1325, 2010. DOI: 10.5012/bkcs.2010.31.5.1319.

[ACM Style]

Kiran Sapkota, Eunyoung Lee, Jae Ho Yang, Youngjoo Kwon, Jongwon Choi, and Younghwa Na. 2010. 4-Hydroxy-2’-Nitrodiphenyl Ether Analogues as Novel Tyrosinase Inhibitors. Bulletin of the Korean Chemical Society, 31, 5, (2010), 1319-1325. DOI: 10.5012/bkcs.2010.31.5.1319.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

ISSN(Print) 0253-2964
ISSN(Online) 1229-5949