Anti-inflammatory and PPAR Subtypes Transactivational Activities of Phenolics and Lignans from the Stem Bark of Kalopanax pictus 


Vol. 32,  No. 11, pp. 4049-4054, Nov.  2011
10.5012/bkcs.2011.32.11.4049


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  Abstract

A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC50 values ranging from 6.2 to 9.1 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with EC50 values ranging from 4.1-12.7 μM. Compounds 4 and 5 exhibited PPARα, PPARγ, and PPARβ(δ) transactivational activities in a dose-dependent manner, with EC50 values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 μM, respectively.

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  Cite this article

[IEEE Style]

T. H. Quang, N. T. T. Ngan, C. V. Minh, P. V. Kiem, N. X. Nhiem, B. H. Tai, N. P. Thao, B. T. T. Luyen, S. B. Song, "Anti-inflammatory and PPAR Subtypes Transactivational Activities of Phenolics and Lignans from the Stem Bark of Kalopanax pictus," Bulletin of the Korean Chemical Society, vol. 32, no. 11, pp. 4049-4054, 2011. DOI: 10.5012/bkcs.2011.32.11.4049.

[ACM Style]

Tran Hong Quang, Nguyen Thi Thanh Ngan, Chau Van Minh, Phan Van Kiem, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Phuong Thao, Bui Thi Thuy Luyen, and Seok Bean Song. 2011. Anti-inflammatory and PPAR Subtypes Transactivational Activities of Phenolics and Lignans from the Stem Bark of Kalopanax pictus. Bulletin of the Korean Chemical Society, 32, 11, (2011), 4049-4054. DOI: 10.5012/bkcs.2011.32.11.4049.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949