Solid-phase Parallel Synthesis of a Novel N-[Alkylsulfonamido-spiro(2H-1-benzopyran- 2,4-piperidine)-6-yl] substituted Amide and Amine Drug-like Libraries 


Vol. 33,  No. 1, pp. 128-136, Jan.  2012
10.5012/bkcs.2012.33.1.128


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  Abstract

We report the solid-phase library construction of 222 number of a novel N-[alkyl sulfonamido-spiro(2H-1- benzopyran-2,4-piperidine)-6-yl] substituted amide 1A and amine 1B derivatives. The polymer-bound N- [alkylsulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted amide 9 and amine 10 derivatives were obtained by first diversity generation with various acid chlorides and alkyl halides. Further reactions on the resins 9 and 10 with substituted sulfonyl chlorides produced the desired N-[alkylsulfonamido-spiro(2H-1- benzopyran-2,4-piperidine)-6-yl] substituted amide 1A and amine 1B analogues.

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  Cite this article

[IEEE Style]

J. Kim, Y. Gong, G. Lee, J. Seo, "Solid-phase Parallel Synthesis of a Novel N-[Alkylsulfonamido-spiro(2H-1-benzopyran- 2,4-piperidine)-6-yl] substituted Amide and Amine Drug-like Libraries," Bulletin of the Korean Chemical Society, vol. 33, no. 1, pp. 128-136, 2012. DOI: 10.5012/bkcs.2012.33.1.128.

[ACM Style]

Ji-Hye Kim, Young-Dae Gong, Gee-Hyung Lee, and Jin-soo Seo. 2012. Solid-phase Parallel Synthesis of a Novel N-[Alkylsulfonamido-spiro(2H-1-benzopyran- 2,4-piperidine)-6-yl] substituted Amide and Amine Drug-like Libraries. Bulletin of the Korean Chemical Society, 33, 1, (2012), 128-136. DOI: 10.5012/bkcs.2012.33.1.128.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949