Design and Synthesis of Oxime Ethers of β-Oxo-γ-phenylbutanoic Acids as PPAR α and -γ Dual Agonists 


Vol. 33,  No. 6, pp. 1979-1982, Jun.  2012
10.5012/bkcs.2012.33.6.1979


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  Abstract

Oxime ethers of β-oxo-γ-phenylbutanoic acids were prepared to develop more effective PPAR α and γ dual agonists. Among them, compound 11k exhibited potent in vitro activities with EC50 of 2.5 nM and 3.3 nM in PPAR α and γ, respectively. It showed better glucose lowering effects than rosiglitazone 1 and improved the lipid profile like plasma triglyceride in db/db mice model.

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  Cite this article

[IEEE Style]

H. O. Han, J. S. Koh, S. H. Kim, O. K. Park, K. Kim, S. K. Jeon, G. Hur, H. J. Yim, G. T. Kim, "Design and Synthesis of Oxime Ethers of β-Oxo-γ-phenylbutanoic Acids as PPAR α and -γ Dual Agonists," Bulletin of the Korean Chemical Society, vol. 33, no. 6, pp. 1979-1982, 2012. DOI: 10.5012/bkcs.2012.33.6.1979.

[ACM Style]

Hee Oon Han, Jong Sung Koh, Seung Hae Kim, Ok Ku Park, Kyoung-Hee Kim, Sang Kweon Jeon, Gwong-Cheung Hur, Hyeon Joo Yim, and Geun Tae Kim. 2012. Design and Synthesis of Oxime Ethers of β-Oxo-γ-phenylbutanoic Acids as PPAR α and -γ Dual Agonists. Bulletin of the Korean Chemical Society, 33, 6, (2012), 1979-1982. DOI: 10.5012/bkcs.2012.33.6.1979.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949