High Yielding [18F]Fluorination Method by Fine Control of the Base 


Vol. 33,  No. 7, pp. 2177-2180, Jul.  2012
10.5012/bkcs.2012.33.7.2177


PDF
  Tumbnail

  Abstract

New [18F]F-fluorination methods using a minimized amount of precursor has been developed by controlling the base concentration. In the first method, pre-conditioning of the anion exchange cartridge with K2CO3 solution or water was carried out. The trapped [18F]fluoride on the cartridge was then eluted by KOMs or KOTf solution. [18F]F-Fluorination could be performed without additional base. In the second method, the QMA cartridge was preconditioned with KOMs solutions. Trapped [18F]fluoride on the QMA was then eluted with KOMs and additional base, such as KOH, K2CO3, and KHCO3, was added into the reaction vessel. Method 1 showed a [18F]F-incorporation yield of 20.9% for [18F]FLT synthesis with 5 mg of precursor. Unlike method 1, a [18F]F-incorporation yield of 91.4% was achieved from the same amount of precursor in method 2.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

S. J. Lee, S. J. Oh, D. Y. Chi, D. H. Moon, J. S. Ryu, "High Yielding [18F]Fluorination Method by Fine Control of the Base," Bulletin of the Korean Chemical Society, vol. 33, no. 7, pp. 2177-2180, 2012. DOI: 10.5012/bkcs.2012.33.7.2177.

[ACM Style]

Sang Ju Lee, Seung Jun Oh, Dae Yoon Chi, Dae Hyuk Moon, and Jin Sook Ryu. 2012. High Yielding [18F]Fluorination Method by Fine Control of the Base. Bulletin of the Korean Chemical Society, 33, 7, (2012), 2177-2180. DOI: 10.5012/bkcs.2012.33.7.2177.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

ISSN(Print) 0253-2964
ISSN(Online) 1229-5949