Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties 


Vol. 33,  No. 8, pp. 2627-2634, Aug.  2012
10.5012/bkcs.2012.33.8.2627


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  Abstract

Strobilurins are one of the most important classes of agricultural fungicides. To discover new strobilurin derivatives with high activity against resistant pathogens, a series of novel β-methoxyacrylate analogues were designed and synthesized by integrating substituted pyrimidine with a strobilurin pharmacophore. The compounds were confirmed and characterized by infrared, 1H nuclear magnetic resonance, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds (1a-1h) exhibited potent antifungal activities against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at the concentration of 50 μg/mL. Exhilaratingly, compound 1d (R=3-trifluoromethylphenyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin.

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  Cite this article

[IEEE Style]

X. Zhang, Y. Gao, H. Liu, B. Guo, H. Wang, "Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties," Bulletin of the Korean Chemical Society, vol. 33, no. 8, pp. 2627-2634, 2012. DOI: 10.5012/bkcs.2012.33.8.2627.

[ACM Style]

Xiang Zhang, Yong-Xin Gao, Hui-Jun Liu, Bao-Yuan Guo, and Hui-Li Wang. 2012. Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties. Bulletin of the Korean Chemical Society, 33, 8, (2012), 2627-2634. DOI: 10.5012/bkcs.2012.33.8.2627.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949