Synthesis and Physicochemical Characterization of Biodegradable PLGA-based Magnetic Nanoparticles Containing Amoxicilin 


Vol. 33,  No. 10, pp. 3225-3232, Oct.  2012
10.5012/bkcs.2012.33.10.3225


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  Abstract

The purposes of this research were to synthesize amoxicillin-carrying magnetic nanoparticles. Magnetic nanoparticles were prepared by a chemical precipitation of ferric and ferrous chloride salts in the presence of a strong basic solution. PLGA and PLGA-PEG copolymers were prepared by ring opening polymerization of lactide (LA) and glycolide (GA) (mole ratio of LA: GA 3:1) with or without polyethylene glycol (PEG). Amoxicillin loaded magnetic PLGA and PLGA-PEG nanoparticles were prepared by an emulsion-evaporation process (o/w). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) photomicrographs showed that the magnetic nanoparticles have the mean diameter within the range of 65-260 nm also they were almost spherical in shape. Magnetic nanoparticles prepared with PLGA showed more efficient entrapment (90%) as compared with PLGA-PEG (48-52%) nanoparticles. In-vitro release of amoxicillin from magnetic PLGA nanoparticles showed that 78% of drug was released over 24 hours. The amount of amoxicillin released from PLGA-PEG s was higher than PLGA.

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  Cite this article

[IEEE Style]

S. Alimohammadi, R. Salehi, N. Amini, S. Davaran, "Synthesis and Physicochemical Characterization of Biodegradable PLGA-based Magnetic Nanoparticles Containing Amoxicilin," Bulletin of the Korean Chemical Society, vol. 33, no. 10, pp. 3225-3232, 2012. DOI: 10.5012/bkcs.2012.33.10.3225.

[ACM Style]

Somayeh Alimohammadi, Roya Salehi, Niloofar Amini, and Soodabeh Davaran. 2012. Synthesis and Physicochemical Characterization of Biodegradable PLGA-based Magnetic Nanoparticles Containing Amoxicilin. Bulletin of the Korean Chemical Society, 33, 10, (2012), 3225-3232. DOI: 10.5012/bkcs.2012.33.10.3225.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949