Thermodynamics of Partitioning of Substance P in Isotropic Acidic Bicelles 


Vol. 34,  No. 3, pp. 743-748, Mar.  2013
10.5012/bkcs.2013.34.3.743


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  Abstract

The temperature dependence of the partition coefficients of a neuropeptide, substance P (SP), in isotropic acidic bicelles was investigated by using a pulsed field gradient nuclear magnetic resonance diffusion technique. The addition of negatively charged dimyristoylphosphatidylserine to the neutral bicelle changed the SP partitioning a little, which implies that the hydrophobic interaction between the hydrophobic residues of SP and the acyl chains of lipid molecules is the major interaction while the electrostatic interaction is minor in SP binding in a lipid membrane. From the temperature dependence of the partition coefficients, thermodynamic functions were calculated. The partitioning of SP into the acidic bicelles is enthalpy-driven, as it is for small unilamellar vesicles and dodecylphosphocholine micelles, while peptide partitioning into a large unilamellar vesicle is entropy-driven. This may mean that the size of lipid membranes is a more important factor for peptide binding than the surface curvature and surface charge density.

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  Cite this article

[IEEE Style]

S. B. Baek, H. J. Lee, H. C. Lee, C. Kim, "Thermodynamics of Partitioning of Substance P in Isotropic Acidic Bicelles," Bulletin of the Korean Chemical Society, vol. 34, no. 3, pp. 743-748, 2013. DOI: 10.5012/bkcs.2013.34.3.743.

[ACM Style]

Seung Bin Baek, Hyeong Ju Lee, Hee Cheon Lee, and Chul Kim. 2013. Thermodynamics of Partitioning of Substance P in Isotropic Acidic Bicelles. Bulletin of the Korean Chemical Society, 34, 3, (2013), 743-748. DOI: 10.5012/bkcs.2013.34.3.743.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949