New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities 


Vol. 34,  No. 3, pp. 827-830, Mar.  2013
10.5012/bkcs.2013.34.3.827


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  Abstract

Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV- 1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 μg/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 μM, respectively.

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  Cite this article

[IEEE Style]

X. Gao, Y. Li, L. Shu, Y. Shen, L. Yang, L. Yang, Z. Yong-Tang, H. Sun, W. Xiao, Q. Hu, "New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities," Bulletin of the Korean Chemical Society, vol. 34, no. 3, pp. 827-830, 2013. DOI: 10.5012/bkcs.2013.34.3.827.

[ACM Style]

Xue-Mei Gao, Yun-Qi Li, Li-Dan Shu, Yan-Qiong Shen, Li-Ying Yang, Liu-Meng Yang, Zheng Yong-Tang, Han-Dong Sun, Wei-Lie Xiao, and Qiu-Fen Hu. 2013. New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities. Bulletin of the Korean Chemical Society, 34, 3, (2013), 827-830. DOI: 10.5012/bkcs.2013.34.3.827.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949