Synthesis of Novel 2'-Spirocyclopropanoid 4'-Deoxythreosyl Phosphonic Acid Nucleoside Analogues 


Vol. 34,  No. 3, pp. 868-874, Mar.  2013
10.5012/bkcs.2013.34.3.868


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  Abstract

Efficient synthetic route to novel 2'-spirocyclopropanoid 4'-deoxythreosyl phosphonic acid nucleosides was described from 1,4-dihydroxy-2-butene. Cyclopropane moiety was prepared via ester enolate alkylation using (2-chloroethyl)dimethylsulfonium iodide. Synthesized nucleoside analogues 16, 19, 23 and 26 were tested for anti-HIV activity as well as cytotoxicity. However, none of them showed any anti-HIV activity or cytotoxicity up to 100 μM.

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  Cite this article

[IEEE Style]

G. H. Shen and J. H. Hong, "Synthesis of Novel 2'-Spirocyclopropanoid 4'-Deoxythreosyl Phosphonic Acid Nucleoside Analogues," Bulletin of the Korean Chemical Society, vol. 34, no. 3, pp. 868-874, 2013. DOI: 10.5012/bkcs.2013.34.3.868.

[ACM Style]

Guang Huan Shen and Joon Hee Hong. 2013. Synthesis of Novel 2'-Spirocyclopropanoid 4'-Deoxythreosyl Phosphonic Acid Nucleoside Analogues. Bulletin of the Korean Chemical Society, 34, 3, (2013), 868-874. DOI: 10.5012/bkcs.2013.34.3.868.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949