Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282) 


Vol. 34,  No. 7, pp. 2011-2015, Jul.  2013
10.5012/bkcs.2013.34.7.2011


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  Abstract

To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)- phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline- 1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.

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  Cite this article

[IEEE Style]

S. Bang, K. Lee, V. K. Sharma, N. Sharma, H. Yang, S. Jung, "Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282)," Bulletin of the Korean Chemical Society, vol. 34, no. 7, pp. 2011-2015, 2013. DOI: 10.5012/bkcs.2013.34.7.2011.

[ACM Style]

Seong-Cheol Bang, Ki-Cheul Lee, Vinay K. Sharma, Niti Sharma, Hyun-Sun Yang, and Sang-Hun Jung. 2013. Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282). Bulletin of the Korean Chemical Society, 34, 7, (2013), 2011-2015. DOI: 10.5012/bkcs.2013.34.7.2011.

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ISSN(Print) 0253-2964
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