Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line 


Vol. 34,  No. 8, pp. 2311-2316, Aug.  2013
10.5012/bkcs.2013.34.8.2311


PDF
  Tumbnail

  Abstract

A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

H. J. Kim, C. Oh, K. H. Yoo, "Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line," Bulletin of the Korean Chemical Society, vol. 34, no. 8, pp. 2311-2316, 2013. DOI: 10.5012/bkcs.2013.34.8.2311.

[ACM Style]

Hee Jin Kim, Chang-Hyun Oh, and Kyung Ho Yoo. 2013. Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line. Bulletin of the Korean Chemical Society, 34, 8, (2013), 2311-2316. DOI: 10.5012/bkcs.2013.34.8.2311.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

ISSN(Print) 0253-2964
ISSN(Online) 1229-5949