Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives 


Vol. 34,  No. 8, pp. 2317-2320, Aug.  2013
10.5012/bkcs.2013.34.8.2317


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  Abstract

Thiourea and vinyl sulfoxide derivatives were designed based on the structures of sulforaphane and gallic acid, prepared and tested for HO-1 inducing activity as a measure of Nrf2 activation, and inhibitory effect on NO production as a measure of anti-inflammatory activity. Both series of compounds showed moderate activity on HO-1 induction, and no inhibitory effect on NO production. Interestingly the thiourea compound 6d showed better HO-1 induction (71% SFN) than the corresponding isothiocyanate compound 6a (55% SFN). Overall, it seemed that more efficient electrophile is needed to get more effective Nrf2 activator.

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  Cite this article

[IEEE Style]

Y. S. Shim, H. S. Hwang, G. Nam, K. I. Choi, "Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives," Bulletin of the Korean Chemical Society, vol. 34, no. 8, pp. 2317-2320, 2013. DOI: 10.5012/bkcs.2013.34.8.2317.

[ACM Style]

Young Sun Shim, Hyun Sook Hwang, Ghilsoo Nam, and Kyung Il Choi. 2013. Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives. Bulletin of the Korean Chemical Society, 34, 8, (2013), 2317-2320. DOI: 10.5012/bkcs.2013.34.8.2317.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949