Molecularly Imprinted Polymers for Solid-Phase Extraction of Sarcosine as Prostate Cancer Biomarker from Human Urine 


Vol. 34,  No. 8, pp. 2330-2334, Aug.  2013
10.5012/bkcs.2013.34.8.2330


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  Abstract

A highly selective molecularly imprinted polymer (MIP) for sarcosine, a cancer marker, was prepared and its use as solid-phase extraction (SPE) sorbent material was demonstrated. The MIP was prepared by a very simple procedure using methacrylic acid as functional monomer and a mixture acetonitrile/water (4/1, v/v) as porogen, overcoming in this way the problems usually related to the imprinting of biological polar compounds. The MIP was tested in batch experiments in order to evaluate its binding properties and then used as SPE sorbent for the selective clean-up and pre-concentration of sarcosine. The extraction protocol was successfully applied to the direct extraction of sarcosine from spiked human urine indicating that the MIP allowed sarcosine to be preconcentrated while simultaneously interfering compounds were removed from the matrix.

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  Cite this article

[IEEE Style]

H. H. M. Rahimian and B. Niromand, "Molecularly Imprinted Polymers for Solid-Phase Extraction of Sarcosine as Prostate Cancer Biomarker from Human Urine," Bulletin of the Korean Chemical Society, vol. 34, no. 8, pp. 2330-2334, 2013. DOI: 10.5012/bkcs.2013.34.8.2330.

[ACM Style]

Hamid Hashemi-Moghaddam Majid Rahimian and Bahman Niromand. 2013. Molecularly Imprinted Polymers for Solid-Phase Extraction of Sarcosine as Prostate Cancer Biomarker from Human Urine. Bulletin of the Korean Chemical Society, 34, 8, (2013), 2330-2334. DOI: 10.5012/bkcs.2013.34.8.2330.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949