Synthesis and Preliminary Cytotoxicity Evaluation of New Diarylamides and Diarylureas Possessing 2,3-Dihydropyrrolo[3,2-b]quinoline Scaffold 


Vol. 34,  No. 8, pp. 2480-2486, Aug.  2013
10.5012/bkcs.2013.34.8.2480


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  Abstract

A new series of diarylamides and diarylureas having 2,3-dihydropyrrolo[3,2-b]quinoline scaffold was synthesized. Their in vitro antiproliferative activities were tested over NCI-60 cancer cell lines of nine different cancer types. Some target compounds showed good inhibition percentages over different cell lines. Among all the target compounds, compound 1f possessing 6,7-dimethoxy-2,3-dihydropyrrolo[3,2-b]quinoline nucleus, amide linker, and 4-chloro-3-(trifluoromethyl)phenyl terminal ring showed high selectivity against MCF7 and MDAMB- 468 breast cancer cell lines more than the other tested cell lines. Its inhibition percentages at 10 μM concentration over those two cell lines were 84.97% and 87.13%, respectively.

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  Cite this article

[IEEE Style]

H. Kim, M. I. El-Gamal, null, Y. S. Lee, C. Oh, "Synthesis and Preliminary Cytotoxicity Evaluation of New Diarylamides and Diarylureas Possessing 2,3-Dihydropyrrolo[3,2-b]quinoline Scaffold," Bulletin of the Korean Chemical Society, vol. 34, no. 8, pp. 2480-2486, 2013. DOI: 10.5012/bkcs.2013.34.8.2480.

[ACM Style]

Hyun-Jin Kim, Mohammed I. El-Gamal, null, Yong Sup Lee, and Chang-Hyun Oh. 2013. Synthesis and Preliminary Cytotoxicity Evaluation of New Diarylamides and Diarylureas Possessing 2,3-Dihydropyrrolo[3,2-b]quinoline Scaffold. Bulletin of the Korean Chemical Society, 34, 8, (2013), 2480-2486. DOI: 10.5012/bkcs.2013.34.8.2480.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949