N-Phenyl-3-Pyridin-2-yl Imino Derivatives as Vascular Smooth Muscle Relaxants: Potential Phosphodiesterase V Inhibitors 


Vol. 34,  No. 9, pp. 2707-2710, Sep.  2013
10.5012/bkcs.2013.34.9.2707


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  Abstract

The present communication deals with development of ten novel N-Phenyl-3-Pyridin-2-yl imino derivatives as vascular smooth muscle relaxants. The derivatives were prepared and optimized using pocket modelling and pharmacophore modelling. The 4 hydroxy substituted derivatives are showed potent activity comparable to the sildenafil.

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[IEEE Style]

P. Choudhari, M. Bhatia, N. Bhatia, "N-Phenyl-3-Pyridin-2-yl Imino Derivatives as Vascular Smooth Muscle Relaxants: Potential Phosphodiesterase V Inhibitors," Bulletin of the Korean Chemical Society, vol. 34, no. 9, pp. 2707-2710, 2013. DOI: 10.5012/bkcs.2013.34.9.2707.

[ACM Style]

Prafulla Choudhari, Manish Bhatia, and Neela Bhatia. 2013. N-Phenyl-3-Pyridin-2-yl Imino Derivatives as Vascular Smooth Muscle Relaxants: Potential Phosphodiesterase V Inhibitors. Bulletin of the Korean Chemical Society, 34, 9, (2013), 2707-2710. DOI: 10.5012/bkcs.2013.34.9.2707.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949