Study on the Inclusion Behavior of Sulfobutylether-β-Cyclodextrin with Perphenazine by Flow Injection Chemiluminescence 


Vol. 34,  No. 11, pp. 3199-3205, Nov.  2013
10.5012/bkcs.2013.34.11.3199


PDF
  Tumbnail

  Abstract

The inclusion behavior of sulfobutylether-β-cyclodextrin (SBE-β-CD) with perphenazine (PPH) was first studied by flow injection (FI)-chemiluminescence (CL) analysis with proposed lg[(I0 – Is)/Is] = lgKP-CD + nlg[CPPH] model and molecular docking. Results showed that a 1:1 complex of SBE-β-CD/PPH could online form, with the formation constant KP-CD of 2.57 × 107 L mol−1 at 298 K. The thermodynamic parameters showed that the inclusion behavior of SBE-β-CD/PPH was a spontaneous process by hydrophobic interaction. The molecular docking results revealed PPH entered into the larger cavity of SBE-β-CD with two hydrogen bonds. Based on the linear relationship of the decrement of luminol/SBE-β-CD/PPH CL intensity against the logarithm of PPH concentration ranging from 0.03 to 30.0 ng mL−1, the present FI-CL analysis using luminol/ SBE-β-CD/PPH system was successfully applied to PPH determination in biological fluids and tablets with recoveries from 94.5 to 105.6% and RSDs less than 2.6% (n = 5).

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

M. Shen, H. Lv, Z. Song, "Study on the Inclusion Behavior of Sulfobutylether-β-Cyclodextrin with Perphenazine by Flow Injection Chemiluminescence," Bulletin of the Korean Chemical Society, vol. 34, no. 11, pp. 3199-3205, 2013. DOI: 10.5012/bkcs.2013.34.11.3199.

[ACM Style]

Minxia Shen, Hairu Lv, and Zhenghua Song. 2013. Study on the Inclusion Behavior of Sulfobutylether-β-Cyclodextrin with Perphenazine by Flow Injection Chemiluminescence. Bulletin of the Korean Chemical Society, 34, 11, (2013), 3199-3205. DOI: 10.5012/bkcs.2013.34.11.3199.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

ISSN(Print) 0253-2964
ISSN(Online) 1229-5949