Butein Disrupts Hsp90’s Molecular Chaperoning Function and Exhibits Anti-proliferative Effects Against Drug-resistant Cancer Cells 


Vol. 34,  No. 11, pp. 3345-3349, Nov.  2013
10.5012/bkcs.2013.34.11.3345


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  Abstract

Hsp90 shows great promise as a therapeutic target due to its potential to disable multiple signaling pathways simultaneously. In this study, we discovered that a natural product, butein moderately inhibited the growth of drug-resistant cancer cells (A2780cis and H1975), and brought about the degradation of oncogenic Hsp90 client proteins. The study demonstrated that butein would be a therapeutic lead to circumvent drug-resistance in cancer chemotherapy. The structure-based screening, synthesis, and biological evaluation of butein are described herein.

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  Cite this article

[IEEE Style]

Y. H. Seo, "Butein Disrupts Hsp90’s Molecular Chaperoning Function and Exhibits Anti-proliferative Effects Against Drug-resistant Cancer Cells," Bulletin of the Korean Chemical Society, vol. 34, no. 11, pp. 3345-3349, 2013. DOI: 10.5012/bkcs.2013.34.11.3345.

[ACM Style]

Young Ho Seo. 2013. Butein Disrupts Hsp90’s Molecular Chaperoning Function and Exhibits Anti-proliferative Effects Against Drug-resistant Cancer Cells. Bulletin of the Korean Chemical Society, 34, 11, (2013), 3345-3349. DOI: 10.5012/bkcs.2013.34.11.3345.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949