Novel Tri- and Tetra-substituted Pyrimido[4,5-d]pyridazines: Regiospecific Synthesis Catalyzed by Silica Supported Yttrium Trinitrate 


Vol. 34,  No. 12, pp. 3677-3680, Dec.  2013
10.5012/bkcs.2013.34.12.3677


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  Abstract

Novel tri- and tetra-substituted pyrimido[4,5-d]pyridazines-2(1H,3H,7H)-ones have been synthesized via the regiospecific condensation reaction of hydrazine derivatives with 5-acetyl-4-aryloyl-6-methyl-3,4-dihydropyrimidinones in the presence of SiO2-Y(NO3)3 as a green and recyclable catalyst under solvent-free conditions. All products were obtained in high yields and short reaction time. Employing this method is in accord with green chemistry principles.

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  Cite this article

[IEEE Style]

B. Karami, S. Akrami, S. Khodabakhshi, "Novel Tri- and Tetra-substituted Pyrimido[4,5-d]pyridazines: Regiospecific Synthesis Catalyzed by Silica Supported Yttrium Trinitrate," Bulletin of the Korean Chemical Society, vol. 34, no. 12, pp. 3677-3680, 2013. DOI: 10.5012/bkcs.2013.34.12.3677.

[ACM Style]

Bahador Karami, Sedigheh Akrami, and Saeed Khodabakhshi. 2013. Novel Tri- and Tetra-substituted Pyrimido[4,5-d]pyridazines: Regiospecific Synthesis Catalyzed by Silica Supported Yttrium Trinitrate. Bulletin of the Korean Chemical Society, 34, 12, (2013), 3677-3680. DOI: 10.5012/bkcs.2013.34.12.3677.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949