A Total Synthesis of Aliskiren Starting from D-Tartrate Diester 


Vol. 34,  No. 12, pp. 3777-3781, Dec.  2013
10.5012/bkcs.2013.34.12.3777


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  Abstract

A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid- cis-bis-lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.

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[IEEE Style]

J. H. Kim and S. Y. Ko, "A Total Synthesis of Aliskiren Starting from D-Tartrate Diester," Bulletin of the Korean Chemical Society, vol. 34, no. 12, pp. 3777-3781, 2013. DOI: 10.5012/bkcs.2013.34.12.3777.

[ACM Style]

Ji Hei Kim and Soo Y. Ko. 2013. A Total Synthesis of Aliskiren Starting from D-Tartrate Diester. Bulletin of the Korean Chemical Society, 34, 12, (2013), 3777-3781. DOI: 10.5012/bkcs.2013.34.12.3777.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949