Three Component Solvent-free Synthesis of Chroman-2,4-dione-based Heterocyclic Ketene Aminal (HKA) Derivatives by “GAP” Chemistry 


Vol. 35,  No. 6, pp. 1625-1632, Jun.  2014
10.5012/bkcs.2014.35.6.1625


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  Abstract

A concise and efficient one-pot synthesis of chroman-2,4-dione-based HKA derivatives by three component reaction of HKAs, triethoxymethane and 4-hydroxycoumarin derivatives under solvent-free and catalyst-free conditions is described. This protocol has many advantages, in that the GAP (Group-Assistant-Purification) chemistry process is involved in this method. As a result, the experimenter can avoid cumbersome process steps such as traditional chromatography and recrystallization purifications. The desired products can be easily obtained by washing the crude products with 95% EtOH.

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  Cite this article

[IEEE Style]

F. Yu, X. Hao, X. Jiang, S. Yan, J. Lin, "Three Component Solvent-free Synthesis of Chroman-2,4-dione-based Heterocyclic Ketene Aminal (HKA) Derivatives by “GAP” Chemistry," Bulletin of the Korean Chemical Society, vol. 35, no. 6, pp. 1625-1632, 2014. DOI: 10.5012/bkcs.2014.35.6.1625.

[ACM Style]

Fu-Chao Yu, Xiao-Pan Hao, Xiu-Yang Jiang, Sheng-Jiao Yan, and Jun Lin. 2014. Three Component Solvent-free Synthesis of Chroman-2,4-dione-based Heterocyclic Ketene Aminal (HKA) Derivatives by “GAP” Chemistry. Bulletin of the Korean Chemical Society, 35, 6, (2014), 1625-1632. DOI: 10.5012/bkcs.2014.35.6.1625.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949