A Facile and Efficient Synthesis of Dronedarone Hydrochloride 


Vol. 35,  No. 7, pp. 1970-1972, Jul.  2014
10.5012/bkcs.2014.35.7.1970


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  Abstract

A facile and efficient synthesis of dronedarone hydrochloride starting from commercially available 4- nitrophenol is described. This approach features a tandem-type synthesis of 3-carbonylated benzofuran involving cyclization of 2-ethynylphenol followed by CO2 fixation at the 3-position of the benzofuran ring mediated by potassium carbonate without the addition of any transition metal catalyst.

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[IEEE Style]

F. Li, C. Jin, J. Zou, J. Wu, "A Facile and Efficient Synthesis of Dronedarone Hydrochloride," Bulletin of the Korean Chemical Society, vol. 35, no. 7, pp. 1970-1972, 2014. DOI: 10.5012/bkcs.2014.35.7.1970.

[ACM Style]

Feng Li, Chunhua Jin, Jianwei Zou, and Jun Wu. 2014. A Facile and Efficient Synthesis of Dronedarone Hydrochloride. Bulletin of the Korean Chemical Society, 35, 7, (2014), 1970-1972. DOI: 10.5012/bkcs.2014.35.7.1970.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949