Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5) 


Vol. 35,  No. 8, pp. 2304-2310, Aug.  2014
10.5012/bkcs.2014.35.8.2304


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  Abstract

The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [11C]MPEQ 3 proved that accumulation of [11C]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.

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  Cite this article

[IEEE Style]

J. Y. Kim, M. Son, K. Choi, D. Baek, M. K. Ko, E. J. Lim, A. N. Pae, G. Keum, J. K. Lee, Y. S. Cho, H. Choo, Y. W. Lee, B. S. Moon, B. C. Lee, H. Lee, S. Min, "Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)," Bulletin of the Korean Chemical Society, vol. 35, no. 8, pp. 2304-2310, 2014. DOI: 10.5012/bkcs.2014.35.8.2304.

[ACM Style]

Ji Young Kim, Myung-Hee Son, Kihang Choi, Du-Jong Baek, Min Kyung Ko, Eun Jeong Lim, Ae Nim Pae, Gyochang Keum, Jae Kyun Lee, Yong Seo Cho, Hyunah Choo, Youn Woo Lee, Byung Seok Moon, Byung Cheol Lee, Ho-Young Lee, and Sun-Joon Min. 2014. Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5). Bulletin of the Korean Chemical Society, 35, 8, (2014), 2304-2310. DOI: 10.5012/bkcs.2014.35.8.2304.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949