Design and Synthesis of Pyrazolyl Thiosemicarbazones as New Anticonvulsants 


Vol. 35,  No. 9, pp. 2733-2737, Sep.  2014
10.5012/bkcs.2014.35.9.2733


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  Abstract

A series of pyrazolyl thiosemicarbazone derivatives were synthesized and evaluated for their anticonvulsant activity using the maximal electroshock (MES) method. Interestingly, all compounds prepared showed long duration of protection effect in the MES screens. Among them, compound 5b was considered as the most promising one with an ED50 value of 47.3 mg/kg, and a PI value of 4.8, which was superior to phenobarbital and valproate in the aspect of safety. Furthermore, compound 5b showed protection against seizures induced by pentylenetetrazole suggesting that compound 5b may exert anticonvulsant activity through GABAmediated mechanisms.

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[IEEE Style]

X. Q. Deng and M. X. Song, "Design and Synthesis of Pyrazolyl Thiosemicarbazones as New Anticonvulsants," Bulletin of the Korean Chemical Society, vol. 35, no. 9, pp. 2733-2737, 2014. DOI: 10.5012/bkcs.2014.35.9.2733.

[ACM Style]

Xian Qing Deng and Ming Xia Song. 2014. Design and Synthesis of Pyrazolyl Thiosemicarbazones as New Anticonvulsants. Bulletin of the Korean Chemical Society, 35, 9, (2014), 2733-2737. DOI: 10.5012/bkcs.2014.35.9.2733.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949