The Protein Kinase 2 Inhibitor CX-4945 Induces Autophagy in Human Cancer Cell Lines 


Vol. 35,  No. 10, pp. 2985-2989, Oct.  2014
10.5012/bkcs.2014.35.10.2985


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  Abstract

Autophagy is a self-digestion process in which intracellular structures are degraded in response to stress. Notably, prolonged autophagy leads to cell death. In this study, we investigated whether CX-4945, an orally available protein kinase 2 (CK2) inhibitor, induces autophagic cell death in human cervical cancer-derived HeLa cells and in human prostate cancer-derived LNCaP cells. CX-4945 treatment of both cell lines resulted in the formation of autophagosomes, in the conversion of microtubule-associated protein 1 light chain 3 (LC3), and in down-regulation of the Akt-mammalian target of rapamycin (mTOR)-p70 ribosomal protein S6 kinase (S6K) signaling cascade. Thus, pharmacologic inhibition of CK2 by CX-4945 induced autophagic cell death in human cancer cells by down-regulating Akt-mTOR-S6K. These results suggest that autophagy-inducing agents have potential as anti-cancer drugs.

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  Cite this article

[IEEE Style]

J. Kim, M. Park, null, B. J. Ryu, S. H. Kim, "The Protein Kinase 2 Inhibitor CX-4945 Induces Autophagy in Human Cancer Cell Lines," Bulletin of the Korean Chemical Society, vol. 35, no. 10, pp. 2985-2989, 2014. DOI: 10.5012/bkcs.2014.35.10.2985.

[ACM Style]

Jiyeon Kim, Mikyung Park, null, Byung Jun Ryu, and Seong Hwan Kim. 2014. The Protein Kinase 2 Inhibitor CX-4945 Induces Autophagy in Human Cancer Cell Lines. Bulletin of the Korean Chemical Society, 35, 10, (2014), 2985-2989. DOI: 10.5012/bkcs.2014.35.10.2985.

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ISSN(Print) 0253-2964
ISSN(Online) 1229-5949